Metabolic inhibitors of bacterial glycan biosynthesis

Mechanisms in protein O-glycan biosynthesis and clinical and molecular aspects of protein O-glycan biosynthesis defects: a review.

BACKGROUND Genetic diseases that affect the biosynthesis of protein O-glycans are a rapidly growing group of disorders. Because this group of disorders does not have a collective name, it is difficult to get an overview of O-glycosylation in relation to human health and disease. Many patients with an unsolved defect in N-glycosylation are found to have an abnormal O-glycosylation as well. It is...

Lipid Biosynthesis Inhibitors

Five classes of herbicides (carbamothioates, chloroacetamides, substituted pyridazinones, cyclohexanediones, and aryloxyphenoxypropionic acids) have been reported to inhibit lipid biosynthesis in higher plants. Carbamothioates impair the synthesis of surface lipids (waxes, cutin, suberin). These effects have been attributed to the ability of this herbicide class to inhibit one or more acyl-CoA ...

Inhibitors of Bacterial Collagenase

Studies on novel bacterial translocase I inhibitors, A-500359s. IV. Biosynthesis of A-500359s.

This report describes the isolation of novel A-500359 analogues from the culture broth of Streptomyces griseus SANK 60196 and 13C-incorporation studies of A-500359 A to reveal the biosynthetic pathway of A-500359 derivatives. As a result, A-500359 M-3 and J were isolated as novel analogues. The former, isolated from a culture broth fed with unnatural amino acids, was a novel amino acid adduct o...

Novel inhibitors of the bacterial de novo purine biosynthesis enzymes, n5-carboxyaminoimidazole ribonucleotide synthetase and mutase

NOVEL INHIBITORS OF THE BACTERIAL DE NOVO PURINEBIOSYNTHESIS ENZYMES, N-CARBOXYAMINOIMIDAZOLERIBONUCLEOTIDE SYNTHETASE AND MUTASEbyMARIA V FAWAZAugust 2012 Advisor: Dr. Steven M. FirestineMajor: Pharmaceutical SciencesDegree: Master of ScienceAntibiotic resistance has seen a significant increase during the past decade. Theincreasing frequency of the drug-...